Nigro G, et al. - As primary maternal cytomegalovirus (CMV) infection during pregnancy is associated with the risk for disease among infants, researchers here sought the factors predictive of infant outcome using a database of 304 pregnant women with primary infection. Between 2010 and 2017, these women were enrolled and delivered 281 infants. Of these infants, 108 were CMV infected. Long term follow-up data were obtained for 173 uninfected and 106 infected infants at age 4 years (range, 1–8 years). Treatment with an average of 2 doses (range, 1–6 doses) of high-dose hyperimmune globulin (HIG: 200 mg/kg/infusion) was received by 157 women. Per findings, maternal viremia was predictive of fetal infection and neonatal outcome. This may aid in counseling patients. Treatment with high-dose HIG may prevent fetal infection and disease and is linked with the resolution of DNAemia.