Wannarong T, et al. - In this prospective study conducted at Siriraj Hospital (Bangkok, Thailand) from November 2013–November 2016, researchers investigated how skin sclerosis burden could affect internal organ involvement over a 1-year period, as measured by time-adjusted accrual-modified Rodnan skin score (TA-mRSS), in patients with systemic sclerosis (SSc). They also focused on the link between TA-mRSS patterns and laboratory tests in these patients. Eligible subjects were SSc patients by ACR/EULAR 2013 or ACR 1980 criteria. Classified as low, intermediate, or high, TA-mRSS was compared between groups. Associations of the arithmetic mean of hemoglobin, erythrocyte sedimentation rate, serum glutamic oxaloacetic transaminase, creatine phosphokinase, and albumin with TA-mRSS were revealed in multiple linear regression analysis. Findings showed a significant association of a higher cumulative course of mRSS over a 1-year period with severe internal organ involvement.