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High burden of serious bacterial infections in African children treated for cancer

The Pediatric Infectious Disease Journal Aug 13, 2020

Naidu G, Izu A, Poyiadjis S, et al. - As there is a lack of studies on the incidence, etiology, risk factors, and outcome of bacterial infections in cancer-treated African children, researchers sought to delineate the epidemiology of infectious morbidity and mortality in children with cancer. The sample consisted of children 1–19 years old with cancer and infections. One hundred sixty-nine children were recruited, 82 with hematologic malignancies and 87 with solid tumors, and 10.7% were HIV infected. Coagulase-negative Staphylococci, Streptococcus viridans and Enterococcus faecium were the most common Gram-positive bacteria, whereas Escherichia coli, Acinetobacter baumannii and Pseudomonas species were the most common Gram-negative bacteria. The study underscores the high burden of sepsis in cancer-treated African children and highlights the correlation of tuberculosis and pneumonia as independent predictors of death in cancer-treated children.

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