Kim AJ, Beam CR, Greenberg NE, et al. - Cognitive decline can be predicted by higher levels of loneliness in older adulthood, so the authors assessed if the relationship between loneliness and general cognitive ability was influenced by multisystemic physiological risk, functional ability, self-rated health, depressive symptoms, and social involvement over a 10-year follow-up in an older adult sample. The sample consisted of 3,005 people with a mean intake age of 69.30 years (SD: 7.85), 51.61% of whom were female. Multisystemic physiological risk did not mediate the link between baseline loneliness and 10-year general cognitive ability, however the effects were significantly mediated by functional ability, self-rated health, depressive symptoms, and social participation. Except for social engagement, indirect effects stayed significant, even after adjustment for demographic covariates and general cognitive ability at 5 years. Cognitive ability can be indirectly influenced by loneliness, signaling that a decline in physical and psychiatric health is more closely related to cognitive ability. In older lonely adults, such mechanisms can serve as targets of cognitive maintenance intervention.