Garcia‐Beltran C, Malpique R, Carbonetto B, et al. - Alteration in gut microbiota has been recorded in girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS. Researchers here examined girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m²) for their gut microbiota composition. In addition, they determined how randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone‐pioglitazone‐metformin (SPIOMET, N = 15) for 1 year affect their gut microbiota composition. Controls were 31 age‐matched girls. Stool samples from all individuals were assessed by performing 16S ribosomal subunit gene amplicon sequencing. Findings revealed reduced diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of Family XI, and less abundance of family Prevotellaceae the genus Prevotella and Senegalimassilia among girls with PCOS vs controls. A positive correlation of Family XI abundance with hepato‐visceral fat was observed. Normalization of the abundance of Family XI was observed with SPIOMET treatment, but not with OC.