Sims TT, Colbert LE, Zheng J, et al. - The 16S rDNA fecal microbiome in 42 individuals with cervical cancer and 46 healthy female controls were identified in order to characterize the change in the gut microbiome of women with locally advanced cervical cancer and contrast it with healthy controls. Within individuals with cervical cancer, bacterial alpha diversity was positively associated with age, however, it exhibited an inverse correlation in controls. In cervical cancer patients, in contrast with controls, alpha diversity was significantly higher, however, stratification by age implied this association was limited to elderly women. Between individuals with cervical cancer and controls, beta diversity also considerably varied. On the basis of age- and race-adjusted LEfSe analysis, multiple taxa significantly varied between individuals with cervical cancer and controls. In patients with cervical cancer, Prevotella, Porphyromonas, and Dialister were significantly enriched, while in healthy people, Bacteroides, Alistipes and members of the Lachnospiracea family were significantly enriched. Hence, this study, among patients with cervical cancer and controls, insinuates variations in gut microbiota diversity and composition. Furthermore, correlation within the gut microbiome by age may highlight etiologic/clinical variations.