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Greater variability in lipid measurements associated with cardiovascular disease and mortality: A 10‐year diabetes cohort study

Diabetes, Obesity and Metabolism Jul 01, 2020

Wan EYF, Yu EYT, Chin WY, et al. - This retrospective cohort analysis was undertaken to assess the links between variability in lipids and the risk of cardiovascular disease (CVD) as well as death among patients having type 2 diabetes depending on low‐density lipoprotein‐cholesterol (LDL‐C), the total cholesterol (TC) to high‐density lipoprotein‐cholesterol (HDL‐C) ratio and triglycerides (TG). This study included 125,047 primary care patients suffering from type 2 diabetes aged 45‐84 years without CVD. Researchers found a 27%, 31% and 9% rise in the risk of composite endpoint of CVD and death in correlation with each unit increment in the variability of LDL‐C (mmol/L), the TC to HDL‐C ratio and TG (mmol/L), respectively. Overall, among primary care patients with type 2 diabetes, findings revealed variability in respective lipids as significant factors in predicting CVD and death, with the strongest impacts associated with LDL‐C and the TC to HDL‐C ratio and most significant in the younger age group (aged 45‐54 years).

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