Guo J, et al. - In 148 middle-aged individuals with childhood-onset type 1 diabetes (T1D) from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study, researchers evaluated whether clinically relevant cognitive impairment was predicted by coronary artery calcification (CAC). The participants had CAC measurements at baseline and repeated 4–8 years later. The study definition of clinically relevant cognitive impairment was two or more of 7 select test scores ≥1.5 SD (standard deviation) worse than demographically appropriate published norms, this definition was met by 28% (41/148) of participants, per extensive neuropsychological testing in 2010–15. Statistical analysis was performed, for which logistic regression models with backward selection were constructed. At first CAC measure, mean age and T1D duration were 37 and 29 years, respectively. Overall, in middle-aged adults with childhood-onset T1D, clinically relevant cognitive impairment was found in association with greater CAC burden. Compared with initial calcification, CAC progression appeared to be a more powerful predictor.