Zhou TL, et al. - In 40- to 75-year-old individuals from The Maastricht Study, researchers investigated cross-sectional associations of greater systolic and diastolic blood pressure variability (BPV) with memory function (n=1,804), information processing speed (n=1,793), and executive function (n=1,780). By standardizing within-visit, 24-hour, and 7-day BPV, they derived a composite BPV-index. They also used linear regression with adjustments for age, sex, educational level, 24-hour systolic or diastolic pressure, and cardiovascular risk factors. Findings revealed a marginal association of a 1-SD greater systolic BPV with lower memory function, but not lower information processing speed and executive function. Lower information processing speed and executive function were observed in association with a 1-SD greater diastolic BPV, which also showed marginal association with lower memory function. Overall, in 40- to 75-year-old, community-dwelling individuals, a greater modifiable risk factor for cognitive deterioration could be very short-term to mid-term diastolic and, to a lesser extent, systolic BPV.