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Greater adherence to secondary prevention medications improves survival after stroke or transient ischemic attack: A linked registry study

Stroke Aug 03, 2021

Dalli LL, Kim J, Cadilhac DA, et al. - Because it's unclear whether greater adherence improves survival after stroke or transient ischemic attack (TIA), researchers looked at associations between medication adherence during the first year postdischarge and mortality up to 3 years to come up with evidence-based targets for medication adherence. A retrospective cohort study of 1-year survivors of first-ever stroke or TIA, aged ≥ 18 years, from the Australian Stroke Clinical Registry (July 2010–June 2014) linked with nationwide prescription refill and mortality information (until August 2017). Adherence to antihypertensive agents, statins, and nonaspirin antithrombotic medications was calculated based on the number of days covered from discharge to 1 year. Data reported that 75% of 8,363 one-year survivors of their first stroke or TIA (44% aged ≥ 75 years, 44% female, 18% TIA), were given antihypertensive agents. Even among patients with near-perfect adherence, higher levels of medication adherence after a stroke or TIA are associated with improved survival. To maximize poststroke survival, interventions to improve medication adherence are required.

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