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Gonadotrophins vs clomiphene citrate with or without IUI in women with normogonadotropic anovulation and clomiphene failure: A cost-effectiveness analysis

Human Reproduction Dec 25, 2018

Bordewijk EM, et al. - Researchers performed an economic evaluation seeking the cost efficacy of six cycles of ovulation induction with gonadotrophins compared to six cycles of ovulation induction with clomiphene citrate (CC) with or without IUI in normogonadotropic anovulatory women not pregnant after six ovulatory cycles with CC. Between December 2008 and December 2015, 666 women in total were allocated to gonadotrophins and IUI (n = 166), gonadotrophins and intercourse (n = 165), CC and IUI (n = 163), or CC and intercourse (n = 172). Outcomes analysis revealed both gonadotrophins and IUI as more expensive when compared with CC and intercourse, and gonadotrophins as more effective than CC.
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