Kobayashi D, et al. - Among the population without diabetes (n = 42,731; mean age was 53.8), defined as those who did not have a known history of diabetes and had normal HbA1c (<6.5%) at their first health check-up, who had voluntary health check-ups, researchers conducted this retrospective cohort study to explore the connection between glycemic variability and malignancy development. This investigation was conducted at a large teaching hospital in Tokyo, Japan, from 2005 to 2016. Two thousand four hundred thirty-five candidates developed malignancies during the median follow up of 2,639 days. Findings revealed that there was a link between large glycemic variability and a high risk of future malignancies in a dose-dependent manner among people without diabetes. Such outcomes indicate that maintaining a constant level of glucose in people without diabetes may have beneficial effects on cancer prevention.