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Glycemic variability and brain glucose levels in T1DM

Diabetes Oct 21, 2018

Hwang JJ, et al. - Amongst T1DM individuals, researchers assessed how glycemic variability impacts brain glucose transport kinetics. For this study, 14 individuals with T1DM and 9 healthy control participants wore a continuous glucose monitor (Dexcom) to measure hypoglycemia, hyperglycemia and glycemic variability for 5 days followed by 1H magnetic resonance spectroscopy scanning in the occipital lobe to measure the change in intracerebral glucose levels during a 2-hour glucose clamp. They found that people with T1DM had significantly smaller increments in intracerebral glucose levels, in spite of a comparable change in plasma glucose levels during the hyperglycemic clamp. It was noted that the change in brain glucose correlated positively with the lability index amongst T1DM individuals.

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