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Glycemic profile of women with normoglycemia and gestational diabetes mellitus during early pregnancy using continuous glucose monitoring system

Diabetes Research and Clinical Practice Sep 03, 2020

Singh C, Gupta Y, Goyal A, et al. - In this cross-sectional study (2017-2019), researchers examined women between 8 and 20 weeks of gestation in order to assess and compare those who have normoglycemia and GDM according to WHO 2013 criteria. Eligible pregnant women had a 75-g oral glucose tolerance test, followed by the placement of a continuous glucose monitoring system. Women (n = 96, 58 with normoglycemia and 38 with GDM) were registered at 14.0 ± 3.2 weeks of gestation. In women with GDM, mean preprandial, 1-h, and 2-h postprandial and peak glucose values were significantly higher. In the normoglycemia and GDM group, peak glucose value was achieved 60.0 ± 12.3 and 64.3 ± 11.6 min after a meal, respectively. In women with GDM, 24-h mean glucose (5.8 ± 0.6 vs. 5.3 ± 0.4 mmol/L), mean daytime glucose (6.0 ± 0.6 vs. 5.5 ± 0.4 mmol/L) and mean nocturnal glucose (5.4 ± 0.7 vs. 5.0 0 ± 0.5 mmol/L) were significantly higher. Compared with the normoglycemia group, the total time spent in range was significantly lower in the GDM group. This investigation underlines variations in glycemic patterns among women with normoglycemia and GDM in the context of a South Asian population where the GDM burden is high but there are limited data on good quality in early pregnancy.

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