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Glycemic markers and subclinical cardiovascular disease: The Jackson Heart Study

Circulation: Cardiovascular Imaging Mar 22, 2019

Echouffo-Tcheugui JB, et al. - Among 4,303 community-dwelling black individuals (64% women; mean age: 54.5 years) without prevalent cardiovascular disease (CVD), researchers examined subclinical CVD in relation to glycemic markers (hemoglobin A1C [HbA1C], fasting plasma glucose, and insulin resistance—homeostasis model assessment of insulin resistance). They found higher odds of coronary artery calcification (CAC), abnormal carotid intima-media thickness (cIMT), and subclinical CVD in relation to each 1% increase in HbA1C. Higher odds of left ventricular (LV) hypertrophy, CAC, abnormal cIMT, and subclinical CVD were reported in relation to each 10-mg/dL rise in fasting plasma glucose. Also, a greater likelihood of developing LV hypertrophy was observed in association with each unit increase in log-transformed homeostasis model assessment of insulin resistance. Overall, differential associations of glycemic markers with various measures of subclinical CVD were identified in this population.

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