Lee RH, et al. - Researchers conducted a retrospective study to determine how glycemic control and insulin treatment influences and modifies fracture risk in older men with type 2 diabetes mellitus. The study sample consisted of 652,901 male veterans (aged ≥ 65 years) with diabetes and baseline hemoglobin A1c (HbA1c) value. Investigators found that among older men with diabetes, those with HbA1c below 6.5% had an increased risk of clinical and hip fractures. They observed that the use of metformin was associated with a lower risk of fracture. Findings suggested an association of insulin use with higher fracture risk, particularly among those with tight glycemic control, and emphasized the significance of therapy regimen in elderly males with diabetes as well as the importance of avoiding hypoglycemia for fracture prevention.