Wang Y, Cao Y, Lebwohl B, et al. - Intake of gluten in adults without celiac disease was not linked with risk of digestive system cancers. For the general population, dietary gluten restriction is unlikely to be useful to the prevention of digestive system malignancies.

• From 3 prospective cohorts, longitudinal data were obtained: the Nurses’ Health Study (1984–2018, 73,166 women aged 65.1 ± 10.8 years), Nurses’ Health Study II (1991–2017, 90,423 women aged 49.1 ± 8.2 years), and Health Professionals Follow-Up Study (1986–2016, 42,617 men aged 64.8 ± 10.8 years).

• Gluten consumption was not linked with an elevated risk of digestive system cancer, post-adjusting for a broad-range of risk factors, including BMI, physical activity, diet quality, with a hazard ratio of 0.94 comparing the highest with the lowest quintile of gluten intake.

• For individual digestive system cancers (including oral cavity and oropharyngeal cancer, esophageal cancer, stomach cancer, small intestine cancer, colorectal cancer, pancreatic cancer, gallbladder cancer, and liver cancer), there were similar null associations.