Angelino D, et al. - In this single-blind, parallel, randomized, placebo-controlled dietary intervention study, researchers focused on changes in inflammatory and glycemia-related markers following consumption of a whole-grain pasta containing barley β-glucans and Bacillus coagulans BC30, 6086 in 41 healthy sedentary overweight (body mass index [BMI] 25–29.9 kg/m²) and obese (BMI ≥30) volunteers (aged 30–65 y) who were low consumers of fruit and vegetables. Participants were asked to consume 1 serving/d of whole-grain control or innovative pasta for 12 wk and to maintain their habitual diets. Plasma high-sensitivity C-reactive protein and fasting plasma lipid profile were primary outcomes. Glycemia-related markers, blood pressure, fecal microbiota composition, and body weight were secondary outcomes. Among overall participants, limited influences of a daily serving of a synbiotic whole-grain pasta on primary and secondary outcomes were observed. However, a subgroup of healthy obese or hyperglycemic volunteers had altered glycemia- and lipid-related markers and resistin because of a daily serving of a synbiotic whole-grain pasta.