Ley B, Alam MS, Kibria MG, et al. - This study was undertaken to investigate if Glucose-6-phosphate dehydrogenase (G6PD) activity varies between individuals with and without malaria or a history of malaria. Researchers enrolled individuals living in the Chittagong Hill Tracts of Bangladesh into 3 complementary studies: conducted a prospective, single-arm clinical efficacy trial including a total of 175 patients with uncomplicated malaria between 2014 and 2015, a cross-sectional survey was performed including a total of 999 individuals between 2015 and 2016 and conducted a matched case-control study including a total of 506 aparasitemic individuals with and without a history of malaria done in 2020. Compared with individuals without malaria, patients with acute malaria had significantly higher G6PD activity, and this could not be accounted for by a protective effect of G6PD deficiency. The findings revealed that G6PD-deficient individuals with malaria may have higher than expected G6PD enzyme activity and an attenuated risk of primaquine-induced hemolysis in comparison with the risk when not infected.