Douros A, et al. - Using the U.K. Clinical Practice Research Datalink, a cohort study was conducted to determine whether the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) was correlated with an increased risk of incident diabetic retinopathy by analyzing data of 77,115 patients with type 2 diabetes initiating antidiabetic drugs between January 2007 and September 2015. According to the type of comparator, the associations with diabetic retinopathy varied. Use of GLP-1 RAs was not related to an increased risk of incident diabetic retinopathy When compared with the use of two or more oral antidiabetic drugs. The study findings suggested that the apparent lower risk of diabetic retinopathy associated with GLP-1 RAs compared with insulin might be due to residual confounding.