Canney M, Tang M, Er L, et al. - In a prospective cohort of asymptomatic patients with chronic kidney disease [median glomerular filtration rate (GFR) = 27 mL/min/1.73 m²], researchers compared GFR-specific cutoffs of each cardiac biomarker [high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)] with standard cutoffs for differentiation of cardiovascular risk. In order to identify optimal risk-based cutoffs for each biomarker within GFR strata (< 20, 20-29, 30-44 mL/min/1.73 m²), they used an outcome-based approach. Both, Hs-cTnT and NT-proBNP, independently enabled the prediction of cardiovascular events. Findings revealed that there were differences in optimal cutoffs for hs-cTnT and NT-proBNP based on GFR level among participants. Also, they found that the performance of these optimal cutoffs was better than that of the standard cutoffs for discrimination of cardiovascular risk. Compared with standard thresholds, higher optimal cutoffs for each biomarker were documented, being highest at GFR values < 20 mL/min/1.73 m².