Glomerular filtration rate change during chronic hepatitis C treatment with sofosbuvir/ledipasvir in HCV/HIV coinfected patients treated with tenofovir and a boosted protease inhibitor: An observational prospective study
BMC Infectious Diseases Aug 09, 2018
Soeiro CASP, et al. - Hepatitis C virus (HCV)/human immunodeficiency virus (HIV) coinfected patients receiving HCV treatment with sofosbuvir/ledipasvir (SOF/LDV) were evaluated for glomerular filtration rate (eGFR) change according to antiretroviral treatment (ARV). Based on ARV regimen, researchers categorized patients into three groups: non tenofovir (TDF), non-boosted TDF, and TDF plus boosted protease inhibitors. All study groups displayed a significant decrease in eGFR during treatment. Following SOF/LDV discontinuation, this decrease was small and reversible. No increased renal toxicity was observed in association with TDF.
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