Sung H, Ferlay J, Siegel RL, et al. - Researchers here used the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer to present an update on the global cancer burden. In 2020, nearly 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and about 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) were reported. Female breast cancer was identified surpassing lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. The leading cause of cancer death remained lung cancer, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Transitioned vs transitioning countries had an overall 2‐fold to 3‐fold higher incidence for both sexes, while mortality varied < 2‐fold for men and little for women. However, transitioning vs transitioned countries had markedly higher death rates for female breast and cervical cancers. As per estimates, they expect a global cancer burden of 28.4 million cases in 2040, a 47% rise from 2020, with a larger rise in transitioning (64% to 95%) vs transitioned (32% to 56%) countries because of demographic modifications, although this may be further aggravated by increasing risk factors linked with globalization and a growing economy. For global cancer control, they emphasize making efforts to develop a sustainable infrastructure for the dissemination of cancer prevention measures and support provision of cancer care in transitioning countries.