Fani L, et al. - Using Cox regression models adjusted for age, sex, and cardiovascular risk factors, researchers analyzed the correlation between global brain perfusion (mL of blood flow/100 mL of brain/min) with risk of transient ischemic attack (TIA) and ischemic stroke in the general population. In addition, they ascertained if retinal vessel calibers, small and large vessel disease, blood pressure, and heart rate had any impact on these correlations. In order to evaluate global brain perfusion, they looked at 5,289 stroke-free participants from the Rotterdam Study underwent phase-contrast brain magnetic resonance imaging between 2005 and 2015. The risk of TIA, but not ischemic stroke, was higher with impaired global brain perfusion in a community-dwelling population. For transient ischemic attack and increased blood pressure for ischemic stroke, this link may be altered by wider arteriolar and venular retinal calibers.