Chawner SJRA, et al. - Researchers sought to describe how copy number variants (CNVs) associated with a high risk of neurodevelopmental and psychiatric disorders (ND-CNVs) influence childhood development and assess if different ND-CNVs lead to specific patterns of cognitive and behavioral outcomes. Using data from the Intellectual Disability and Mental Health: Assessing the Genomic Impact on Neurodevelopment (IMAGINE-ID) study, they recruited 2,819 children aged 4 years and older with pathogenic CNV or single nucleotide variants via the UK National Health Service medical genetic clinic network and patient support groups to complete broad online phenotyping. Among these children, they approached 258 (9%) children who had one ND-CNV of interest, with 13 CNVs across nine loci and their families, for a deep phenotyping, home-based assessment. As per findings, childhood neurodevelopment was similarly adversely affected by the 13 studied ND-CNVs, regardless of subtle quantitative and qualitative variances. They noted pleiotropic effects of genomic risk for neuropsychiatric disorder on multiple processes and neural circuits and signifying the need to avoid focusing on single phenotypes in future research.