Jung SY, Scott PA, Papp JC, et al. - Since immune-associated etiologic pathways to impact invasive breast cancer risk may interact with lifestyle factors, but the interrelated molecular genetic pathways are not fully defined, therefore, researchers performed this study utilizing data from the Women's Health Initiative Database for Genotypes and Phenotypes Study incorporating 16,088 postmenopausal women. With 21,784,812 common autosomal single-nucleotide polymorphisms (SNPs), they carried out a genome-wide association (GWA) gene-environment interaction study in 6 independent GWA Studies for pro-inflammatory cytokines as well as their gene-lifestyle interactions. Experts discovered a number of new top markers for C-reactive protein and interleukin-6, which displayed an interaction with obesity factors. Breast cancer risk was shown to be impacted by a substantial proportion of those SNPs' susceptibility. Via this study, a better insight into genetic links between pro-inflammation and cancer may be gained. In view of the findings, intervention strategies were suggested for women who have the risk genotypes, attenuating breast cancer risk.