Ge J, et al. - Via a larger meta-analysis of 14 formerly published genome-wide association study (GWAS) datasets in the Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Study with 53,107 patients of European descent, researchers sought to substantiate the association of the overall genetic variation measured by single nucleotide polymorphisms (SNPs) in the nucleotide excision repair (NER) pathway with breast cancer (BC) risk. One hundred thirty-eight candidate genes were selected from the NER pathway using the “Molecular Signatures Database (MsigDB)” and “PathCards.” Association of following four independent SNPs with BC risk was observed: BIVM-ERCC5rs1323697_C, GTF2H4 rs1264308_T, COPS2 rs141308737_C deletion, and ELL rs1469412_C. BC risk was also correlated with their combined genetic score. Correlation of BIVM-ERCC5rs1323697 C and ELL rs1469412 C alleles with increased mRNA expression of their genes was observed in 373 lymphoblastoid cell lines. Probably through modulating their corresponding gene expression, findings suggest a possible biological part played by these SNPs in BC etiology.