Djuric O, Andjelkovic M, Vreca M, et al. - Researchers here examined how 8 different single nucleotide variants (SNVs) within tumor necrosis factor alpha ( TNFA), lymphotoxin alpha ( LTA) and Toll-like receptor (TLR2 and TLR4) genes associate with the risk of posttraumatic sepsis. In the emergency department of the Clinical Centre of Serbia, they conducted a nested case-control study including 228 traumatized patients (44 with sepsis and 184 without sepsis). They included a control group of 101 healthy persons to perform comparison of the results of trauma individuals. Using the real-time PCR method, they performed genotyping of TNFA (rs1800629 and rs361525), LTA (rs909253), TLR2 (rs3804099, rs4696480 and rs3804100), and TLR4 (rs4986790 and rs4986791) for all patients within all three groups. Per findings, significant risk of posttraumatic sepsis is conferred by rare allele carriage within TNFA rs1800629 and TLR4 rs4986791 genetic variants. In silico programs have labeled TLR4 gene variants (rs4986790 and rs4986791) as disease causing.