Meier SM, Trontti K, Purves KL, et al. - Researchers sought for genetic variants that are associated with anxiety and stress-related disorders. In addition, they investigated whether these genetic variants correlate with other traits. In this genome-wide association study, they included individuals with various anxiety and stress-related diagnoses (n = 12,655) and controls (n = 19,225) derived from the population-based Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) study. They performed further evaluation of genes of interest in mice exposed to chronic social defeat. Findings emphasize anxiety and stress-related disorders as complex heritable phenotypes with intriguing genetic correlations with psychiatric traits as well as with educational outcomes and multiple obesity-related phenotypes. Further, there appeared a robust association of PDE4B variants with anxiety and stress-related disorders indicating to the potential of PDE4B inhibitors in the treatment of these disorders.