Liu C et al. - A literature review was performed to update that status of what is known about single nucleotide polymorphisms (SNPs) and lung cancer risk.

Methods
A literature search was performed and 198 studies were identified which addressed the associations between 108 SNPs and lung cancer.

Results
Among the 108 SNPs, 63 were associated with lung cancer and the remaining 45 were non-significant.
15 SNPs on or near 12 genes and 1 miRNA had strong evidence of an association with lung cancer risk, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and −819C/T), and TP53 (intron 6).
All of the 29 SNPs identified in 12 genome-wide association studies were proved to be noteworthy based on false-positive report probability.