Brhane Y, Yang P, Christiani DC, et al. - Researchers conducted the largest genomic investigation on the lung cancer prognosis of never smokers to date using the International Lung Cancer Consortium (ILCCO) to evaluate genetic determinants for lung cancer prognosis among these patients. Researchers included genomic and clinical data from 1,569 never-smoking lung cancer patients of European ancestry from 10 ILCCO studies. They evaluated hazard ratios (HRs) and 95% confidence intervals of overall survival. Based on 1,553 normal lung tissues from the Lung expression quantitative trait loci dataset and, they evaluated if the correlations were mediated through mRNA expression. They tested the correlations in a Japanese study (N=887) For cross-ethnicity generalization. It was shown that inherited genetic variants can affect lung cancer prognosis. One locus near LMO7DN was found at a genome-wide level as well as several potential prognostic genes with cis-effect on mRNA expression. To assess their role in tumor progression, future functional genomics work is needed.