Sullivan BA, Qin X, Redding TS, et al. - Researchers explored the connections between known colorectal cancer (CRC)-risk single nucleotide polymorphisms (SNPs) and rising cumulative adenoma counts. A total of 612 selected candidates aged 50-75 years with genotyped blood samples and 10 years of clinical follow up were included in the Cooperative Studies Program #380 screening colonoscopy cohort. Using eight published SNPs related to multiple adenomas, deemed "adenoma-risk SNPs," experts developed a polygenic risk score (PRS). rs12241008 (gene: VTI1A), rs2423279 (BMP2/HAO1), rs3184504 (SH2B3), and rs961253 (FERMT1/BMP2) were the four CRC-risk SNPs that were identified to be related to increasing cumulative adenoma counts. Overall, a number of recognized CRC-risk SNPs were shown to be related to increasing cumulative adenoma counts and the finding of ≥ 10 cumulative adenomas in this predominantly male veteran CRC screening cohort. A higher cumulative number of adenomas was reported in relation to an increasing burden of adenoma-risk SNPs, ascertained by a weighted PRS.