Andrews A, Maharaj A, Cottrell E, et al. - This study was undertaken to explore genetic characterization of short stature patients referred with suspected growth hormone insensitivity (GHI) and features which overlapped with known GH-IGF-I axis defects. The center received 149 GHI referrals for genetic testing between 2008 and 2020. Researchers present a wide range of diagnoses in 149 patients referred with suspected GHI, which emphasizes the need to recognize GHI as a spectrum of clinical entities in undiagnosed short stature patients. There is a need for detailed clinical and genetic assessment to distinguish a diagnosis and inform clinical management.