Bussaneli DG, et al. - Authors assessed the possible relationship between polymorphisms in immune response-related genes and molar-incisor hypomineralization (MIH), and their interaction with polymorphisms in amelogenesis-related genes. A correlation was demonstrated by this family-based study between variation in TGFBR1 and molar-incisor hypomineralization (MIH). Furthermore, in immune response and amelogenesis genes, the polymorphisms may have an additive effect on the risk of developing MIH.