Menghini-Müller S, et al. - Researchers examined 336 patients with an at-risk mental state (ARMS) for psychosis (159 women) for gender differences in symptomatology, drug use, comorbidity (i.e. substance use, affective and anxiety disorders) and global functioning. The sample was recruited from the prodromal work package of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI; 11 centers). Significantly higher rates of negative symptoms and current cannabis use were reported in men while higher rates of general psychopathology with more frequent comorbid affective and anxiety disorders were noted in women. As per findings, ARMS display gender differences in symptomatology and comorbidity similar to those seen in overt psychosis and in healthy controls. However, observed differences are small and studies with high statistical power would only reliably detect these differences. Moreover, the clinical value of such small effects may be insignificant.