Hoffman GE, Ma Y, Montgomery KS, et al. - With respect to age of onset, symptomatology and course of the disease, schizophrenia differs between males and females, so researchers sought to determine the molecular mechanisms underlying these disparities. A large-scale transcriptome analysis was performed including RNA-seq data from 437 controls and 341 cases from two distinct cohorts from the CommonMind Consortium. A reproducible gene expression signature of schizophrenia was identified in analysis across the cohorts; this gene expression signature is noted to be highly concordant with prior work. Results overall revealed that there is small effect size of gender disparities in schizophrenia gene expression signatures, underscoring the challenge of recognizing robust gender-by-diagnosis signatures, which will necessitate future analyses in larger cohorts.