Abraham DS, Gruber-Baldini AL, Magder LS, et al. - In a large clinical cohort involving 914 males and 549 females, researchers analyzed differences in presentation, physician- and patient-reported Parkinson disease (PD) outcomes, and progression by gender. With five-year piecewise linear mixed-effects models, gender differences in the progression of impairment, disability, and health-related quality of life (HRQoL) were tested. Compared with males, females had significantly less social support, more psychological distress, and worse self-reported (but not physician-reported) disability and HRQoL at initial PD care visits. Addressing the symptoms of anxiety may mitigate this difference. Overall, the authors concluded that there is no disparity in PD progression by gender, but patient-reported severity measures are worse in females than in males. Psychological distress screening and management, especially targeting females, should be introduced as part of PD clinical care to attenuate this gender difference in the experience of the disease.