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Gender differences in masked hypertension: The Coronary Artery Risk Development in Young Adults study

Journal of Hypertension Nov 14, 2019

Pugliese DN, Booth JN, Deng L, et al. - Researchers used multivariable adjusted models and analyzed 658 participants who had 24-h ambulatory blood pressure monitoring (ABPM) and had clinic SBP/DBP less than 140/90 mmHg during the Year 30 Exam of the Coronary Artery Risk Development in Young Adults study, to assess gender disparities in the prevalence of masked hypertension and the variation between awake, or alternatively 24-h, ambulatory blood pressure (BP) and clinic BP. Participants had a mean age of 54.8 years, 58.4% were women, and 58.2% were black. For any masked hypertension, the prevalence was estimated to be 37.5% and 60.6% among women and men, respectively, which represents a high prevalence of masked hypertension on ABPM in both genders. For any masked hypertension, masked awake, 24-h and asleep hypertension, the prevalence ratios comparing men vs women were estimated to be 1.39, 1.60, 1.71, and 1.40, respectively, in a model including adjustment for demographics, cardiovascular risk factors, antihypertensive medication, and clinic BP. For SBP and for DBP, the differences between mean awake ambulatory BP and clinic BP were estimated to be 2.75 mmHg higher and 3.61 mmHg higher, respectively, among men vs women, in a fully adjusted model. Male gender was identified as an independent predictor of masked hypertension.
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