Fix RL, et al. - Using a nationally representative sample of 4,181 youth from the Add Health dataset, researchers studied the mediational pathways from child sexual abuse to risky sexual behavior to sexually transmitted infections (STIs), and further assessed the role of depressive symptomatology and nonmedical prescription drug use on the connection between child sexual abuse and risky sexual behavior. Moreover, as moderators, race and gender were examined to account for potential different effects of these mechanisms on females and males as well as on different racial and ethnic groups. Outcomes from a moderated mediation model showed risky sexual behavior partially mediated the path from child sexual abuse to contraction of STI, and the use of depressive symptomatology and non-medical prescription drug partially mediated the path from child sexual abuse to risky sexual behavior. The relationship between risky sexual behavior and STI contraction was moderated by race and gender. Adolescents emphasized the need for STI prevention efforts to focus on risk factors beyond risky sexual behaviors, such as childhood sexual abuse and mental health screening that includes depressive symptomatology and the use of non-medical prescription drugs.