Nübel J, Truthmann J, Heidemann C, et al. - Evidence suggests that depression is associated with an increased risk of type 2 diabetes (T2D). Researchers herein investigated how major depressive disorder (MDD) influences prospective glycemic changes.

• Participants (n = 1,766 adults without diabetes; 776 men, 990 women; 18–65 years of age) from the mental health supplement of the German National Health Interview and Examination Survey (GNHIES98-MHS, 1997–1999) and a follow-up survey (DEGS1, 2008–2011) were assessed in this cohort study.

• MDD was prevalent in 21.4% of women and 8.9% of men.

• Among women, a lower chance for remission was observed in correlation MDD.

• Among men, there appeared no significant correlation of MDD with glycemic changes.

• No significant effect of MDD on incident T2D was evident.

• Findings overall emphasize the role of depression in T2D prevention, especially among women.