Fisher LK, Wang X, Tun TA, et al. - Utilizing computational modelling and optical coherence tomography (OCT), researchers sought to evaluate gaze evoked deformations of the optic nerve head (ONH) in thyroid eye disease (TED). Multiple finite element models have been developed: one model of a healthy eye, and two models that mimic TED effects; one with proptosis and one with extraocular tissue stiffening. In the computational models, the eyes with proptosis and stiffer extraocular tissue had greater gaze-evoked deformations compared with the healthy eye model, whereas the models with softer or no extraocular tissue had lesser deformations, in both adduction and abduction. Computational modelling and experimental observation indicate that TED may cause increased gaze-evoked deformations of the ONH.