Shin JW, et al. - Among 357 glaucoma suspects (541 eyes) with mean follow-up duration of 5.7 years, researchers ascertained if progressive macular ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thinning predict the development of VF defects, defined as the presence of three consecutive abnormal VFs. A Guided Progression Analysis (GPA) in optical coherence tomography (OCT) was used to assess progressive GCIPL and RNFL thinning. Using Cox proportional hazard models, the risk of developing VF defect was assessed. According to results, 74 eyes and 87 eyes exhibited progressive GCIPL and RNFL thinning in OCT GPA, respectively, and 40 eyes developed VF defects. The eyes showed a significantly higher risk of developing VF defects with progressive GCIPL and RNFL thinning. Findings suggested that monitoring progressive changes in both GCIPL and RNFL effectively predicts the development of VF defects in glaucoma suspects.