Chen JJ, Chang CH, Huang YT, et al. - To ascertain the diagnostic performance of the furosemide stress test (FST) in predicting acute kidney injury (AKI) progression, researchers performed this systemic review and meta-analysis following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. They explored the PubMed, Embase, and Cochrane databases up to March 2020, and identified 11 trials with 1,366 patients. For the prediction of AKI progression, the FST yielded a pooled sensitivity and specificity of 0.81 and 0.88, respectively. The pooled positive likelihood ratio (LR) and the pooled negative LR were 5.45 and 0.26, respectively, and the pooled diagnostic odds ratio was identified to be 29.69. For renal replacement therapy (RRT) prediction, the pooled sensitivity and specificity results of the FST were found to be 0.84 and 0.77, respectively. The pooled positive LR was 3.16 and pooled negative LR was 0.25. Overall, it was concluded that FST affords a simple tool that enables the detection of AKI populations carrying a high risk of AKI progression and the requirement for RRT, and FST displayed a better diagnostic performance for RRT prediction in early AKI population.