Santoro A, Piermattei A, Inzani F, et al. - Researchers performed a retrospective study including patients who underwent surgery with intraoperative evaluation (IOE) for suspected endometrial carcinoma (EC) in order to evaluate the agreement rate between IOE and final diagnosis (FD) in these patients. They analyzed data of 202 women who had a preoperative ambiguous or inconclusive diagnosis by endometrial biopsies and imaging. IOE evaluation led to the identification of Endometrioid (n = 180) and Non-Endometrioid (n = 22) pathology in 180 and 22 patients, respectively. They observed an overall agreement rate of 93,07% when the comparison between the frozen section (FS) and the definitive histological subtype was done; for Endometrioid and Non-Endometrioid tumors, an agreement of 97.2% vs 59%, respectively, was observed. Findings thereby indicate good agreement between intraoperative grading, myometrial invasion and their histological definition on permanent sections. This underscores FS as a good predictor for the surgical outcomes, especially in the presence of a preoperative ambiguous or inconclusive diagnostic evaluation.