Cardona ID, et al. - A randomized, single-blind, crossover-controlled trial was conducted in children 6 months to 11 years of age with moderate-to-severe atopic dermatitis (AD), to assess the efficacy of twice-daily soaking baths, followed by immediate use of an occlusive moisturizer (ie, soak-and-seal [SS]), vs twice-weekly SS baths, in the acute management of pediatric AD. Researchers randomly assigned 1:1 the participants to 2 groups: group 1 had twice-weekly SS baths, for 10 minutes or less, over 2 weeks (“dry method” [DM]) followed by twice-daily SS baths, for 15 to 20 minutes, over 2 weeks (“wet method” [WM]). They asked the group 2 to do the inverse. They screened overall 63 children, of those, 42 satisfied the inclusion criteria and were randomized. The study was completed by 40 (95%). Findings revealed the superior efficacy of WM as an acute treatment intervention, vs DM, for improving disease severity in moderate-to-severe pediatric AD.