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Frequency, risk factors, and outcomes of non-occlusive mesenteric ischaemia after cardiac arrest

Resuscitation Oct 07, 2020

Paul M, Bougouin W, Legriel S, et al. - The frequency, risk factors, and outcomes of non-occlusive mesenteric ischaemia (NOMI) after cardiac arrest (CA) were investigated via retrospectively assessing patients admitted to a CA center with sustained return of spontaneous circulation between 2007 and 2017. They suspected NOMI based on clinical symptoms and classified it as possible if no tests were feasible or the only test was a negative abdominal computed tomography (CT) scan and as confirmed if diagnosed by endoscopy, CT, or surgery. Among 1,343 included patients, NOMI was suspected in 82 (6%) patients, including 33 (2.5%) with confirmed NOMI. Multivariate analysis revealed following factors to be linked with suspected NOMI: female gender, cardiovascular comorbidities, admission lactate > 5 mmol/L, low flow > 17 minutes, and inotropic score > 7 μg/kg/min. ICU mortality of 96% (79/82) was observed, with 61% of patients dying from multi-organ failure (MOF) and 35% from postanoxic brain injury. Findings thereby suggest that 2.5% to 6% of patients may be affected by NOMI after CA. Extremely high mortality was reported in patients, with very few surviving with a good neurological outcome.

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