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Freeze-all vs fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles: Multicentre randomised controlled trial

BMJ Aug 11, 2020

Stormlund S, Sopa N, Zedeler A, et al. - Via this multicentre, randomized controlled superiority trial, the ongoing pregnancy rate was determined between a freeze-all strategy vs a fresh transfer strategy in assisted reproductive technology treatment. Participants were 460 women aged 18-39 years with regular menstrual cycles initiating their first, second, or third treatment cycle of in vitro fertilization or intracytoplasmic sperm injection at any of the outpatient fertility clinics at eight public hospitals in Denmark, Sweden, and Spain. At baseline, they performed randomization of women on cycle day 2 or 3 to one of two treatment groups: the freeze-all group (elective freezing of all embryos) who received gonadotropin releasing hormone agonist triggering and single frozen-thawed blastocyst transfer in a subsequent modified natural cycle; or the fresh transfer group who received human chorionic gonadotropin triggering and single blastocyst transfer in the fresh cycle. Outcomes revealed no higher ongoing pregnancy and live birth rates among women with regular menstrual cycles in correlation with a freeze-all strategy with gonadotropin releasing hormone agonist triggering for final oocyte maturation vs a fresh transfer strategy. 

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