Fernando SM, McIsaac DI, Rochwerg B, et al. - In this retrospective analysis (2011–2016), researchers assessed results of ICU patients (≥ 18 years of age) receiving invasive mechanical ventilation in correlation with frailty, defined by the Clinical Frailty Scale (CFS). They used a prospectively gathered registry from two hospitals. CFS scores depended on recorded preadmission function at the time of hospital admission. Hospital mortality (primary outcome), as well as discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy (secondary outcomes), were evaluated. Of overall 8,110 patients included, frailty (CFS ≥ 5) was detected in 2,529 (31.2%). Increased odds of hospital mortality, discharge to long-term care, extubation failure, and demand for tracheostomy were observed in relation to the presence of frailty among patients receiving mechanical ventilation.