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Fracture risk following high-trauma versus low-trauma fracture: a registry- based cohort study

Osteoporosis International Mar 22, 2020

Leslie WD, Schousboe JT, Morin SN, et al. - In this study, bone mineral density (BMD) measurements and risk of subsequent low-trauma fracture were compared in individuals with prior high- or low-trauma fractures. Researchers applied a clinical BMD registry for the province of Manitoba, Canada, to distinguish women and men age 40 years or older with fracture records from linked population-based healthcare data. They assessed age- and gender-adjusted BMD Z-scores and covariate-adjusted hazard ratios (HR) with 95% confidence intervals (CI) for incident fracture in relation to prior fracture status, categorized as high-trauma if associated with external injury codes and low-trauma otherwise. This analysis included a total of 64,428 women and men with no prior fracture (mean age 63.7 years), 858 with prior high-trauma fractures (mean age 65.1 years), and 14,758 with prior low-trauma fractures (mean age 67.2 years). The outcomes of this study indicated that high-trauma and low-trauma fractures showed similar relationships with low BMD and future fracture risk. This indicates the inclusion of high-trauma fractures in clinical evaluation for underlying osteoporosis and in the assessment for intervention to minimize future fracture risk.

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