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Fractal analysis of polypoidal choroidal neovascularisation in age-related macular degeneration

British Journal of Ophthalmology Sep 10, 2020

Rita S, Coscas F, Pinna A, et al. - Researchers conducted the study for describing optical coherence tomography angiography (OCTA) features of polypoidal choroidal neovascularisation (PCNV) secondary to age-related macular degeneration. Based on clinical and multimodal imaging, a retrospective consecutive series of 51 patients with a diagnosis of PCNV was analyzed. All patients with PCNV had a comprehensive ophthalmological examination, involving fluorescein and indocyanine green angiography, structural optical coherence tomography (OCT) and OCTA. Fifty-one PCNV eyes were involved in the analysis.  No significant difference was observed between PCNVs displaying a different OCTA pattern, in terms of quantitative OCTA parameters. The fractal analysis provides quantitative parameters which show that PCNVs with different OCTA patterns share the same neovascular architecture and complexity of branching. Such new findings strengthen the ability to interpret OCTA slabs, opening new areas of debate about this type of neovascular lesion.

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